Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? | PLOS Genetics
A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ | PLOS ONE
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms | ACS Chemical Biology
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DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
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Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender - ScienceDirect
Science Signaling - The DNA polymerase Pol-kappa endows tumor cells with resistance to the BRAF inhibitor vemurafenib without increasing mutagenesis, according to new research from the White lab. https://fcld.ly/5jaum2s Credit: K. Temprine
![RCSB PDB - 6BS1: Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion RCSB PDB - 6BS1: Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion](https://cdn.rcsb.org/images/structures/bs/6bs1/6bs1_assembly-1.jpeg)
RCSB PDB - 6BS1: Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? | PLOS Genetics
![DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/c219b9fb-161b-4f61-b050-7391981444f7/jcp30155-fig-0004-m.jpg)
DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
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Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function | Scientific Reports
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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites | PNAS
![DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/d5949214-64eb-4cb1-ad3d-df759d63ea38/jcp30155-fig-0006-m.jpg)
DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
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